Thrombopoietin levels increased in patients with severe acute respiratory syndrome.
Identifieur interne : 002F80 ( Main/Exploration ); précédent : 002F79; suivant : 002F81Thrombopoietin levels increased in patients with severe acute respiratory syndrome.
Auteurs : Mo Yang [République populaire de Chine] ; Margaret H L. Ng ; Chi Kong Li ; Paul K S. Chan ; Chang Liu ; Jie Yu Ye ; Beng H. ChongSource :
- Thrombosis research [ 0049-3848 ] ; 2008.
Descripteurs français
- KwdFr :
- Analyse de régression, Antigènes CD34 (biosynthèse), Cellules souches, Cellules souches hématopoïétiques (cytologie), Facteur de croissance transformant bêta (immunologie), Humains, Microscopie de fluorescence, Modèles biologiques, Mégacaryocytes (cytologie), Régulation de l'expression des gènes, Syndrome respiratoire aigu sévère (sang), Syndrome respiratoire aigu sévère (virologie), Test ELISA (), Thrombopoïétine (biosynthèse), Thrombopénie (génétique), Thrombopénie (sang), Virus du SRAS (métabolisme).
- MESH :
- biosynthèse : Antigènes CD34, Thrombopoïétine.
- cytologie : Cellules souches hématopoïétiques, Mégacaryocytes.
- génétique : Thrombopénie.
- immunologie : Facteur de croissance transformant bêta.
- métabolisme : Virus du SRAS.
- sang : Syndrome respiratoire aigu sévère, Thrombopénie.
- virologie : Syndrome respiratoire aigu sévère.
- Analyse de régression, Cellules souches, Humains, Microscopie de fluorescence, Modèles biologiques, Régulation de l'expression des gènes, Test ELISA.
English descriptors
- KwdEn :
- Antigens, CD34 (biosynthesis), Enzyme-Linked Immunosorbent Assay (methods), Gene Expression Regulation, Hematopoietic Stem Cells (cytology), Humans, Megakaryocytes (cytology), Microscopy, Fluorescence, Models, Biological, Regression Analysis, SARS Virus (metabolism), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (virology), Stem Cells, Thrombocytopenia (blood), Thrombocytopenia (genetics), Thrombopoietin (biosynthesis), Transforming Growth Factor beta (immunology).
- MESH :
- chemical , biosynthesis : Antigens, CD34, Thrombopoietin.
- blood : Severe Acute Respiratory Syndrome, Thrombocytopenia.
- cytology : Hematopoietic Stem Cells, Megakaryocytes.
- genetics : Thrombocytopenia.
- chemical , immunology : Transforming Growth Factor beta.
- metabolism : SARS Virus.
- methods : Enzyme-Linked Immunosorbent Assay.
- virology : Severe Acute Respiratory Syndrome.
- Gene Expression Regulation, Humans, Microscopy, Fluorescence, Models, Biological, Regression Analysis, Stem Cells.
Abstract
Hematological changes in patients with Severe Acute Respiratory Syndrome (SARS) are common and frequently include thrombocytopenia. Using a ELISA method, we found an increase in thrombopoietin (TPO) levels in the plasma of convalesced SARS patients (290+/-53 pg/ml) and active SARS patients (251+/-23 pg/ml) comparing to that from normal control patients (228+/-17 pg/ml). In addition, the plasma from active SARS patients had an inhibitory effect on CFU-MK formation, which could be neutralized by anti-TGF-beta antibodies. In the experiment to determine whether SARS-CoV can directly infect hematopoietic stem cells and megakaryocytic cells, incubation of the cells with SARS-CoV did not show active infection. Our findings of increased TPO levels in the plasma of SARS patients provide a possible explanation for the genesis of thrombocytosis, which frequently develops from thrombocytopenia in SARS patients.
DOI: 10.1016/j.thromres.2007.12.021
PubMed: 18314161
Affiliations:
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Ng</name></author><author><name sortKey="Li, Chi Kong" sort="Li, Chi Kong" uniqKey="Li C" first="Chi Kong" last="Li">Chi Kong Li</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name></author><author><name sortKey="Liu, Chang" sort="Liu, Chang" uniqKey="Liu C" first="Chang" last="Liu">Chang Liu</name></author><author><name sortKey="Ye, Jie Yu" sort="Ye, Jie Yu" uniqKey="Ye J" first="Jie Yu" last="Ye">Jie Yu Ye</name></author><author><name sortKey="Chong, Beng H" sort="Chong, Beng H" uniqKey="Chong B" first="Beng H" last="Chong">Beng H. Chong</name></author></analytic><series><title level="j">Thrombosis research</title><idno type="ISSN">0049-3848</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, CD34 (biosynthesis)</term><term>Enzyme-Linked Immunosorbent Assay (methods)</term><term>Gene Expression Regulation</term><term>Hematopoietic Stem Cells (cytology)</term><term>Humans</term><term>Megakaryocytes (cytology)</term><term>Microscopy, Fluorescence</term><term>Models, Biological</term><term>Regression Analysis</term><term>SARS Virus (metabolism)</term><term>Severe Acute Respiratory Syndrome (blood)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Stem Cells</term><term>Thrombocytopenia (blood)</term><term>Thrombocytopenia (genetics)</term><term>Thrombopoietin (biosynthesis)</term><term>Transforming Growth Factor beta (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de régression</term><term>Antigènes CD34 (biosynthèse)</term><term>Cellules souches</term><term>Cellules souches hématopoïétiques (cytologie)</term><term>Facteur de croissance transformant bêta (immunologie)</term><term>Humains</term><term>Microscopie de fluorescence</term><term>Modèles biologiques</term><term>Mégacaryocytes (cytologie)</term><term>Régulation de l'expression des gènes</term><term>Syndrome respiratoire aigu sévère (sang)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Test ELISA ()</term><term>Thrombopoïétine (biosynthèse)</term><term>Thrombopénie (génétique)</term><term>Thrombopénie (sang)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antigens, CD34</term><term>Thrombopoietin</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Antigènes CD34</term><term>Thrombopoïétine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term><term>Thrombocytopenia</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches hématopoïétiques</term><term>Mégacaryocytes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Hematopoietic Stem Cells</term><term>Megakaryocytes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Thrombocytopenia</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Thrombopénie</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Facteur de croissance transformant bêta</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Thrombopénie</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation</term><term>Humans</term><term>Microscopy, Fluorescence</term><term>Models, Biological</term><term>Regression Analysis</term><term>Stem Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de régression</term><term>Cellules souches</term><term>Humains</term><term>Microscopie de fluorescence</term><term>Modèles biologiques</term><term>Régulation de l'expression des gènes</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hematological changes in patients with Severe Acute Respiratory Syndrome (SARS) are common and frequently include thrombocytopenia. Using a ELISA method, we found an increase in thrombopoietin (TPO) levels in the plasma of convalesced SARS patients (290+/-53 pg/ml) and active SARS patients (251+/-23 pg/ml) comparing to that from normal control patients (228+/-17 pg/ml). In addition, the plasma from active SARS patients had an inhibitory effect on CFU-MK formation, which could be neutralized by anti-TGF-beta antibodies. In the experiment to determine whether SARS-CoV can directly infect hematopoietic stem cells and megakaryocytic cells, incubation of the cells with SARS-CoV did not show active infection. Our findings of increased TPO levels in the plasma of SARS patients provide a possible explanation for the genesis of thrombocytosis, which frequently develops from thrombocytopenia in SARS patients.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name><name sortKey="Chong, Beng H" sort="Chong, Beng H" uniqKey="Chong B" first="Beng H" last="Chong">Beng H. Chong</name><name sortKey="Li, Chi Kong" sort="Li, Chi Kong" uniqKey="Li C" first="Chi Kong" last="Li">Chi Kong Li</name><name sortKey="Liu, Chang" sort="Liu, Chang" uniqKey="Liu C" first="Chang" last="Liu">Chang Liu</name><name sortKey="Ng, Margaret H L" sort="Ng, Margaret H L" uniqKey="Ng M" first="Margaret H L" last="Ng">Margaret H L. Ng</name><name sortKey="Ye, Jie Yu" sort="Ye, Jie Yu" uniqKey="Ye J" first="Jie Yu" last="Ye">Jie Yu Ye</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Mo" sort="Yang, Mo" uniqKey="Yang M" first="Mo" last="Yang">Mo Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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